Research areas

  1. Published

    Role of in vitro release models in formulation development and quality control of parenteral depots

    Larsen, C. S., Larsen, Susan Weng, Jensen, H., Yaghmur, Anan & Østergaard, Jesper, 2009, In: Expert Opinion on Drug Delivery. 6, 12, p. 1283-1295

    Research output: Contribution to journalReviewResearch

  2. Published

    Controlled release - macromolecular prodrugs

    Larsen, C. S., Østergaard, Jesper & Larsen, Susan Weng, 2007, Prodrugs: challenges and rewards. Stella, V. J., Borchardt, R. T., Hageman, M. J., Oliyai, R., Maag, H. & Tilley, J. W. (eds.). New York: Springer, p. 379-416

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  3. Published

    Reaction between drug substances and pharmaceutical excipients: formation of citric acid esters and amides of carvedilol in the solid state

    Larsen, J., Cornett, Claus, Jaroszewski, J. W. & Hansen, S. H., 2009, In: Journal of Pharmaceutical and Biomedical Analysis. 49, 1, p. 11-17

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Identification of reaction products between drug substances and excipients by HPLC-SPE-NMR: Ester and amide formation between citric acid and 5-aminosalicylic acid

    Larsen, J. T., Stærk, Dan, Cornett, Claus, Hansen, S. H. & Jaroszewski, J. W., 2009, In: Journal of Pharmaceutical and Biomedical Analysis. 49, p. 839-842

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Impurities in drugs: Analysis of drug-excipient reactions

    Larsen, J. T., 2010, Det Farmaceutiske Fakultet. 99 p.

    Research output: Book/ReportPh.D. thesis

  6. Published

    Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan

    Larsen, M., Larsen, R., Jensen, K. G., Larsen, Birger Brodin & Nielsen, C. U., 2009, In: British Journal of Pharmacology. 157, p. 1380-1389

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: Characterization of conditions for affinity and transport experiments in Caco-2 cells.

    Larsen, M., Larsen, Birger Brodin, Frølund, Bente & Nielsen, C. U., 2008, In: European Journal of Pharmaceutical Sciences. 35, 1-2, p. 86-95

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Computeren er medicinalkemikerens arbejdshest

    Larsen, S. B., Olsen, L. & Jørgensen, Flemming Steen, 2009, In: Lægemiddelforskning. p. 7-9

    Research output: Contribution to journalJournal articleCommunication

  9. Published

    Computational studies of the human peptide transporter (hPEPT1) and development of tools for virtual screening

    Larsen, S. B., 2010, København: Det Farmaceutiske Fakultet. 111 p.

    Research output: Book/ReportPh.D. thesis

  10. Published

    Palladium-catalyzed monoamination of dihalogenated benzenes

    Larsen, S. B., Bang-Andersen, B., Johansen, Tommy Nørskov & Jørgensen, M., 2008, In: Tetrahedron. 64, 13, p. 2938-2950

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Discovery of ligands for the human intestinal di-/tripeptide transporter (hPEPT1) using af QSAR-assisted virtual screening strategy

    Larsen, S. B., Omkvist, D. H., Larsen, Birger Brodin, Nielsen, C. U., Steffansen, B., Olsen, L. & Jørgensen, Flemming Steen, 2009, In: ChemMedChem. 4, 9, p. 1439-1445

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Forbedret optagelse af lægemidler i organismen: computeren viser vejen

    Larsen, S. B., Jørgensen, Flemming Steen & Olsen, L., 2010, In: Dansk Kemi. 91, 6/7, p. 18-20

    Research output: Contribution to journalJournal articleResearch

  13. Published

    QSAR models for the human H+/peptide symporter, hPEPT1: Affinity prediction using alignment-independent descriptors

    Larsen, S. B., Jørgensen, Flemming Steen & Olsen, L., 2008, In: Journal of Chemical Information and Modeling. 48, 1, p. 233-241

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Critical factors influencing the In Vivo performance of long-acting liophilic solutions - impact on In Vitro release method design

    Larsen, Susan Weng & Larsen, C. S., 2009, In: The AAPS Journal. 11, 4, p. 762-770

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Assessment of drug release from oil depot formulations using an in vitro model: Potential applicability in accelerated release testing

    Larsen, Susan Weng, Jessen, M. N. B., Østergaard, Jesper & Larsen, C. S., 2008, In: Drug Development and Industrial Pharmacy. 34, 3, p. 297-304

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    On the mechanism of drug release from oil suspensions in vitro using local anasthetics as model drug compounds

    Larsen, Susan Weng, Frost, A. B., Østergaard, Jesper, Marcher, H. & Larsen, C. S., 2008, In: European Journal of Pharmaceutical Sciences. 34, 1, p. 37-44

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Diflunisal salts of bupivacaine, lidocaine and morphine. Use of the common ion effect for prolonging the release of bupivacaine from mixed salt suspensions in an in vitro dialysis model

    Larsen, Susan Weng, Østergaard, Jesper, Poulsen, S., Schulz, B. & Larsen, C. S., 2007, In: European Journal of Pharmaceutical Sciences. 31, 3-4, p. 172-179

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice.

    Larsen, S. T., Hansen, J. S., Hansen, E. W., Clausen, P. A. & Nielsen, G. D., 2007, In: Toxicology. 235, 1-2, p. 119-129

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Human urine as test material in 1H NMR-based metabonomics: recommendations for sample preparation and storage

    Lauridsen, M., Hansen, S. H., Jaroszewski, J. W. & Cornett, Claus, 2007, In: Analytical Chemistry. 79, 3, p. 1181-1186

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Application of the FLIPSY pulse sequence for increased sensitivity in 1H NMR-based metabolic profiling studies

    Lauridsen, M., Maher, A. D., Keun, H., Lindon, J. C., Nicholson, J. K., Nyberg, N. T., Hansen, S. H., Cornett, Claus & Jaroszewski, J. W., 2008, In: Analytical Chemistry. 80, 9, p. 3365-3371

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Fast and direct recognition of the active ingredients in tablets using hot cell membrane inlet mass spectrometry

    Lauritsen, F. R. & Nielsen, K., 2010, In: International Journal of Mass Spectrometry. 295, p. 119-123

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Maternal intake of fish oil but not of linseed oil reduces the the antibody response in neonatal mice

    Lauritzen, Lotte, Kjær, T. M. R., Porsgaard, T., Fruekilde, M., Mu, Huiling & Frøkiær, Hanne, 2011, In: Lipids. 46, 2, p. 171-178 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

    Laustsen, A. H. & Lohse, B., 15 Sep 2015, In: Toxicon. 104, p. 43-45 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  24. Published

    Quantitative chemical transformations for the synthesis and modification of peptidomimetics on solid phase

    Le Quement, S. T., 2007, København: Det Farmaceutiske Fakultet. 190 p.

    Research output: Book/ReportPh.D. thesis

  25. Published

    Design space approach in the optimization of the spray-drying process

    Lebrun, P., Krier, F., Mantanus, J., Grohganz, Holger, Yang, Mingshi, Rozet, E., Boulanger, B., Evrard, B., Rantanen, Jukka & Hubert, P., 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 80, 1

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Praktiske erfaringer med maskinel dosisdispensering af medicin (MD)

    Lee, A., Nørgaard, Lotte Stig & Herborg, H., 2007, In: Sygeplejersken. 21, p. 52-6

    Research output: Contribution to journalJournal articleResearch

  27. Published

    Particle size dependence of polymorphism in spray-dried mannitol

    Lee, Y., Wu, J., Yang, Mingshi, Young, P. M., van der Berg, Franciscus Winfried J & Rantanen, Jukka, 2011, In: European Journal of Pharmaceutical Sciences. 44, 1-2, p. 41-48

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action

    Lehmann, A., Antonsson, M., Holmberg, A. A., Blackshaw, L. A., Brändén, L., Bräuner, Hans, Christiansen, B., Dent, J., Elebring, T., Jacobson, B., Jensen, J., Mattsson, J. P., Nilsson, K., Oja, S. S., Page, A. J., Saransaari, P. & von Unge, S., 2009, In: Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 504-512

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice

    Lehre, A. C., Rowley, N. M., Zhou, Y., Holmseth, S., Guo, C., Holen, T., Hua, R., Laake, P., Olofsson, A. M., Poblete-Naredo, I., Rusakov, D. A., Madsen, K. K., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Danbolt, N. C., 1 Jun 2011, In: Epilepsy Research. 95, 1-2, p. 70-81

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Solvent-mediated solid phase transformations of carbamazepine: effects of simulated intestinal fluid and fasted state simulated intestinal fluid

    Lehto, P., Aaltonen, J., Tenho, M., Rantanen, Jukka, Hirvonen, J., Tanninen, V. P. & Peltonen, L., 2009, In: Journal of Pharmaceutical Sciences. 98, 3, p. 985-996

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Simultaneous measurement of liquid-phase and solid-phase transformation kinetics in rotating disc and channel flow cell dissolution devices

    Lehto, P., Aaltonen, J., Niemelä, P., Rantanen, Jukka, Hirvonen, J., Tanninen, V. P. & Peltonen, L., 2008, In: Internation Journal of Pharmaceutics. 363, 1-2, p. 66-72

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Demonstration of neuron-glia transfer of precursors for Gaba biosynthesis in a co-culture system of dissociated mouse cerebral cortex

    Leke, R., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2008, In: Neurochemical Research. 33, 12, p. 2629-2635

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

    Leke, R., Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Schousboe, Arne & Waagepetersen, Helle S., 1 Jun 2011, In: Journal of Neurochemistry. 117, 5, p. 824-32 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Characterization of barley leaf tissue using direct and indirect desorption electrospray ionization imaging mass spectrometry

    Li, B., Bjarnholt, Nanna, Hansen, S. H. & Janfelt, Christian, 2011, In: Journal of Mass Spectrometry. 46, 12, p. 1241-1246

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    New human milk fat substitutes from butterfat to improve fat absorption

    Li, Yanqi, Mu, Huiling, Andersen, J. E. T., Xu, X., Meyer, O. & Ørngreen, A., 2010, In: Food Research International. 43, p. 739-744

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Preliminary environmental risk assessment of the parasiticide ivermectin

    Liebig, M., Boxall, A., Duis, K., Egeler, P., Garric, J., Halling-Sørensen, B., Knacker, T., Krogh, K. A. & Küster, A., 2007.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  37. Published

    Environmental risk assessment of ivermectin - A case study with a veterinary pharmaceutical

    Liebig, M., Fernandez, A. A., Blübaum-Gronau, E., Boxall, A., Duis, K., Egeler, P., Fenner, K., Fink, G., Garric, J., Halling-Sørensen, B., Jensen, J., Knacker, T., Krogh, K. A., Küster, A., Pope, L., Römbke, J., Rönnefahrt, I., Argüello, P. S., Schneider, M., Tait, A. & 3 others, Tarazona, J., Ternes, T. & Werhan, A., 2008, World under stress: scientific and applied issues in environmental toxicology and chemistry. Society of Environmental Toxicology and Chemistry, p. 28-28

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearch

  38. Published

    Environmental risk assessment of ivermectin: A case study

    Liebig, M., Fernandez, Á. A., Blübaum-Gronau, E., Boxall, A., Brinke, M., Carbonell, G., Egeler, P., Fenner, K., Fernandez, C., Fink, G., Garric, J., Halling-Sørensen, B., Knacker, T., Krogh, K. A., Küster, A., Löffler, D., Cots, M. Á. P., Pope, L., Prasse, C., Römbke, J. & 8 others, Rönnefahrt, I., Schneider, M. K., Schweitzer, N., Tarazone, J. V., Ternes, T. A., Traunspurger, W., Wehrhan, A. & Duis, K., 2010, In: Integrated Environmental Assessment and Management. 6, Suppl. 1, p. 567-587

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Increased litter size and super-ovulation rate in congenic C57BL mice carrying a polymorphic fragment of NFR/N origin at the Fecq4 locus of chromosome 9

    Liljander, M., Andersson, Åsa, Holmdahl, R. & Mattsson, R., 2009, In: Genetics Research. 91, 4, p. 259-65 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2 fragments

    Liljander, M., Andersson, Åsa, Holmdahl, R. & Mattsson, R., 2008, In: Arthritis Research & Therapy. 10, 4, p. R88 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Molecular recognition in ligand-protein binding

    Liljefors, T., 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 15-27

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  42. Published

    Knowledge-sharing practices in pharmaceutical research and development—a case study.

    Lilleoere, A. & Hansen, E. H., 2011, In: Knowledge and Process Management (Print Edition). 18, 3, p. 121-132 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Knowledge creation processes in researceh and development: a case study in the pharmaceutical industry

    Lilleøre, A., 2010, København: Museum Tusculanum. 67 p.

    Research output: Book/ReportPh.D. thesis

  44. Published

    Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80

    Lind, M. L., Jacobsen, Jette, Holm, R. & Mullertz, Anette , 2008, In: European Journal of Pharmaceutical Sciences. 35, 3, p. 211-218

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms

    Lind, M. L., Jacobsen, Jette, Holm, R. & Mullertz, Anette , 2007, In: European Journal of Pharmaceutical Sciences. 32, 4-5, p. 261-270

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes

    Lindvall, T., Karlsson, J., Holmdahl, R. & Andersson, Åsa, 2009, In: Arthritis Research & Therapy. 11, 1, p. R10

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Do family practitioners in Lithuania inform their patients about adverse effects of common medications?

    Liseckiene, I., Liubarskiene, Z., Jacobsen, Ramune, Valius, L. & Norup, M. S., 2008, In: Journal of Medical Ethics. 34, 3, p. 137-140

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    MCF-7 human mammary adenocarcinoma cells exhibit augmented responses to human insulin on a collagen IV surface

    Listov-Saabye, N., Jensen, M. B., Kiehr, B., Hansen, E. W., Svendsen, J. E., Lundby, A., Holm, G. N. & Oleksiewicz, M. B., 2009, In: Journal of Applied Toxicology. 29, 6, p. 470-7

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

    Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, Michael, Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 19 Sep 2011, In: Angewandte Chemie International Edition. 50, 39, p. 9100-9103

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    In vitro dissolution

    Lomstein Pedersen, B. & Müllertz, A., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage from evaluation. Steffansen, B., Brodin, B. & Uhd Nielsen, C. (eds.). Pharmaceutical Press, p. 257-273

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch