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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. / Shen, Xueyi; Howard, David M.; Adams, Mark J.; Hill, W. David; Clarke, Toni Kim; Adams, Mark J.; Clarke, Toni Kim; McIntosh, Andrew M.; Deary, Ian J.; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Agerbo, Esben; Air, Tracy M.; Andlauer, Till F.M.; Bacanu, Silviu Alin; Bækvad-Hansen, Marie; Beekman, Aartjan T.F.; Bigdeli, Tim B.; Binder, Elisabeth B.; Bryois, Julien; Buttenschøn, Henriette N.; Bybjerg-Grauholm, Jonas; Cai, Na; Castelao, Enrique; Christensen, Jane Hvarregaard; Coleman, Jonathan R.I.; Colodro-Conde, Lucía; Couvy-Duchesne, Baptiste; Craddock, Nick; Crawford, Gregory E.; Davies, Gail; Degenhardt, Franziska; Derks, Eske M.; Direk, Nese; Dolan, Conor V.; Dunn, Erin C.; Eley, Thalia C.; Escott-Price, Valentina; Kiadeh, Farnush Farhadi Hassan; Finucane, Hilary K.; Foo, Jerome C.; Hansen, Christine Søholm; Hansen, Thomas F.; Pedersen, Carsten Bøcker; Nordentoft, Merete; Werge, Thomas; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.
In:
Nature Communications, Vol. 11, No. 1, 2301, 2020.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Shen, X, Howard, DM, Adams, MJ, Hill, WD, Clarke, TK, Adams, MJ, Clarke, TK, McIntosh, AM, Deary, IJ, Wray, NR, Ripke, S, Mattheisen, M, Trzaskowski, M, Byrne, EM, Abdellaoui, A, Agerbo, E, Air, TM, Andlauer, TFM, Bacanu, SA, Bækvad-Hansen, M, Beekman, ATF, Bigdeli, TB, Binder, EB, Bryois, J, Buttenschøn, HN, Bybjerg-Grauholm, J, Cai, N, Castelao, E, Christensen, JH, Coleman, JRI, Colodro-Conde, L, Couvy-Duchesne, B, Craddock, N, Crawford, GE, Davies, G, Degenhardt, F, Derks, EM, Direk, N, Dolan, CV, Dunn, EC, Eley, TC, Escott-Price, V, Kiadeh, FFH, Finucane, HK, Foo, JC, Hansen, CS, Hansen, TF, Pedersen, CB
, Nordentoft, M, Werge, T & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2020, '
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank',
Nature Communications, vol. 11, no. 1, 2301.
https://doi.org/10.1038/s41467-020-16022-0APA
Shen, X., Howard, D. M., Adams, M. J., Hill, W. D., Clarke, T. K., Adams, M. J., Clarke, T. K., McIntosh, A. M., Deary, I. J., Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Agerbo, E., Air, T. M., Andlauer, T. F. M., Bacanu, S. A., ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2020).
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.
Nature Communications,
11(1), [2301].
https://doi.org/10.1038/s41467-020-16022-0Vancouver
Shen X, Howard DM, Adams MJ, Hill WD, Clarke TK, Adams MJ et al.
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.
Nature Communications. 2020;11(1). 2301.
https://doi.org/10.1038/s41467-020-16022-0Author
Shen, Xueyi ; Howard, David M. ; Adams, Mark J. ; Hill, W. David ; Clarke, Toni Kim ; Adams, Mark J. ; Clarke, Toni Kim ; McIntosh, Andrew M. ; Deary, Ian J. ; Wray, Naomi R. ; Ripke, Stephan ; Mattheisen, Manuel ; Trzaskowski, Maciej ; Byrne, Enda M. ; Abdellaoui, Abdel ; Agerbo, Esben ; Air, Tracy M. ; Andlauer, Till F.M. ; Bacanu, Silviu Alin ; Bækvad-Hansen, Marie ; Beekman, Aartjan T.F. ; Bigdeli, Tim B. ; Binder, Elisabeth B. ; Bryois, Julien ; Buttenschøn, Henriette N. ; Bybjerg-Grauholm, Jonas ; Cai, Na ; Castelao, Enrique ; Christensen, Jane Hvarregaard ; Coleman, Jonathan R.I. ; Colodro-Conde, Lucía ; Couvy-Duchesne, Baptiste ; Craddock, Nick ; Crawford, Gregory E. ; Davies, Gail ; Degenhardt, Franziska ; Derks, Eske M. ; Direk, Nese ; Dolan, Conor V. ; Dunn, Erin C. ; Eley, Thalia C. ; Escott-Price, Valentina ; Kiadeh, Farnush Farhadi Hassan ; Finucane, Hilary K. ; Foo, Jerome C. ; Hansen, Christine Søholm ; Hansen, Thomas F. ; Pedersen, Carsten Bøcker ; Nordentoft, Merete ; Werge, Thomas ; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. / A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. In: Nature Communications. 2020 ; Vol. 11, No. 1.
Bibtex
@article{d74bc82d9d8045808cb7aebca532694b,
title = "A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank",
abstract = "Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, pFDR < 0.043). Several behavioural traits are also associated with depression-PRS (β: 0.014 to 0.180, pFDR: 0.049 to 1.28 × 10−14) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression.",
author = "Xueyi Shen and Howard, {David M.} and Adams, {Mark J.} and Hill, {W. David} and Clarke, {Toni Kim} and Adams, {Mark J.} and Clarke, {Toni Kim} and McIntosh, {Andrew M.} and Deary, {Ian J.} and Wray, {Naomi R.} and Stephan Ripke and Manuel Mattheisen and Maciej Trzaskowski and Byrne, {Enda M.} and Abdel Abdellaoui and Esben Agerbo and Air, {Tracy M.} and Andlauer, {Till F.M.} and Bacanu, {Silviu Alin} and Marie B{\ae}kvad-Hansen and Beekman, {Aartjan T.F.} and Bigdeli, {Tim B.} and Binder, {Elisabeth B.} and Julien Bryois and Buttensch{\o}n, {Henriette N.} and Jonas Bybjerg-Grauholm and Na Cai and Enrique Castelao and Christensen, {Jane Hvarregaard} and Coleman, {Jonathan R.I.} and Luc{\'i}a Colodro-Conde and Baptiste Couvy-Duchesne and Nick Craddock and Crawford, {Gregory E.} and Gail Davies and Franziska Degenhardt and Derks, {Eske M.} and Nese Direk and Dolan, {Conor V.} and Dunn, {Erin C.} and Eley, {Thalia C.} and Valentina Escott-Price and Kiadeh, {Farnush Farhadi Hassan} and Finucane, {Hilary K.} and Foo, {Jerome C.} and Hansen, {Christine S{\o}holm} and Hansen, {Thomas F.} and Pedersen, {Carsten B{\o}cker} and Merete Nordentoft and Thomas Werge and {Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium}",
year = "2020",
doi = "10.1038/s41467-020-16022-0",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",
}
RIS
TY - JOUR
T1 - A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
AU - Shen, Xueyi
AU - Howard, David M.
AU - Adams, Mark J.
AU - Hill, W. David
AU - Clarke, Toni Kim
AU - Adams, Mark J.
AU - Clarke, Toni Kim
AU - McIntosh, Andrew M.
AU - Deary, Ian J.
AU - Wray, Naomi R.
AU - Ripke, Stephan
AU - Mattheisen, Manuel
AU - Trzaskowski, Maciej
AU - Byrne, Enda M.
AU - Abdellaoui, Abdel
AU - Agerbo, Esben
AU - Air, Tracy M.
AU - Andlauer, Till F.M.
AU - Bacanu, Silviu Alin
AU - Bækvad-Hansen, Marie
AU - Beekman, Aartjan T.F.
AU - Bigdeli, Tim B.
AU - Binder, Elisabeth B.
AU - Bryois, Julien
AU - Buttenschøn, Henriette N.
AU - Bybjerg-Grauholm, Jonas
AU - Cai, Na
AU - Castelao, Enrique
AU - Christensen, Jane Hvarregaard
AU - Coleman, Jonathan R.I.
AU - Colodro-Conde, Lucía
AU - Couvy-Duchesne, Baptiste
AU - Craddock, Nick
AU - Crawford, Gregory E.
AU - Davies, Gail
AU - Degenhardt, Franziska
AU - Derks, Eske M.
AU - Direk, Nese
AU - Dolan, Conor V.
AU - Dunn, Erin C.
AU - Eley, Thalia C.
AU - Escott-Price, Valentina
AU - Kiadeh, Farnush Farhadi Hassan
AU - Finucane, Hilary K.
AU - Foo, Jerome C.
AU - Hansen, Christine Søholm
AU - Hansen, Thomas F.
AU - Pedersen, Carsten Bøcker
AU - Nordentoft, Merete
AU - Werge, Thomas
AU - Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
PY - 2020
Y1 - 2020
N2 - Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, pFDR < 0.043). Several behavioural traits are also associated with depression-PRS (β: 0.014 to 0.180, pFDR: 0.049 to 1.28 × 10−14) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression.
AB - Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, pFDR < 0.043). Several behavioural traits are also associated with depression-PRS (β: 0.014 to 0.180, pFDR: 0.049 to 1.28 × 10−14) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression.
U2 - 10.1038/s41467-020-16022-0
DO - 10.1038/s41467-020-16022-0
M3 - Journal article
C2 - 32385265
AN - SCOPUS:85084721245
VL - 11
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 2301
ER -
