CRISPR gene-therapy. Critical review of ethical concerns and a proposal for public decision-making

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CRISPR is currently viewed as the central tool for future gene-therapy. Yet, many prominent scientists and bioethicists have expressed ethical concerns around CRISPR gene-therapy. The paper provides critical review of concerns about CRISPR gene-therapy as expressed in mainstream academic literature, paired with replies also generally found in that literature. The expressed concerns can be categorised into three types depending on whether they stress risk/benefit ratio, autonomy and informed consent, or concerns related to various aspects of justice. In the reviewed literature, we found no intrinsic objections to CRISPR gene-therapy, even though many of such objections were present in discussions of gene-editing in the 90s. Hereafter, the paper proposes a brief outline for a practically applicable moral framework for public decision-making about CRISPR gene-therapy, and suggest how such a framework might be supported. We also suggest that this framework should also govern public engagement about CRISPR gene-therapy in order to reduce the risk that we make decisions about CRISPR gene-therapy based on misperceptions, inflated views of risk, or unreasonable moral or religious views.
Original languageEnglish
JournalCanadian Journal of Bioethics
Issue number2
Publication statusAccepted/In press - 2022

ID: 298477095