Thomas Bentin
Guest Researcher
Transcription, RNA, and Gene Medicine Program
Blegdamsvej 3
2200 København N.
Current research
Recently, we initiated work in the field of chromosome biology. We have developed novel chromosome locus-specific live-cell imaging technology using Cas9 derivatives. We aim to observe how certain conditions impact specific human chromosomal loci. We hope to generate a deeper understanding of chromosome dynamics and in particular of cancer-associated loci. This work is a collaboration with Ian D. Hickson and the Center for Chromosome Stability.
Previously, we discovered how chaperonins impact bacterial resistance to translation corrupting antibiotics. We have uncovered criteria for engineering of mRNAs with predictable translation outputs. Using mutant aminoacyl-tRNA synthetases, we introduced synthetic photo-reactive amino acid into the genetic code of E. coli. We engineered a novel GFP variant aiming to develop a reporter for translational fidelity. We studied how DNA topology impact mRNA transcription and peptide nucleic acid binding to dsDNA.
Teaching
I teach cell biology and molecular biology for medical students, and other students. I also mentor bachelors, masters and/or Ph.D. students doing their research projects.
ID: 5313
Most downloads
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218
downloads
Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
190
downloads
The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes
Research output: Contribution to journal › Journal article › Research › peer-review
Published